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| DATE | MATCHUP | SPREAD | MONEY | TOTAL |
|---|---|---|---|---|
| Wednesday, May. 21, 12:40 pm |
Cincinnati Reds at | (-1.5) 135 | -121 | (O: 8) -110 |
| Pittsburgh Pirates | (+1.5) -155 | +110 | (U: 8) -112 | |
| Wednesday, May. 21, 01:15 pm |
Chicago Cubs at | (-1.5) 115 | -140 | (O: 9) +100 |
| Miami Marlins | (+1.5) -135 | +125 | (U: 9) -120 | |
| Wednesday, May. 21, 06:50 pm |
Atlanta Braves at | (-1.5) 107 | -150 | (O: 8.5) -110 |
| Washington Nationals | (+1.5) -125 | +131 | (U: 8.5) -110 | |
| Wednesday, May. 21, 08:45 pm |
Philadelphia Phillies at | (-1.5) -155 | -228 | (O: 11.5) -110 |
| Colorado Rockies | (+1.5) +135 | +198 | (U: 11.5) -110 | |
| Wednesday, May. 21, 10:15 pm |
Arizona Diamondbacks at | (+1.5) -170 | +118 | (O: 9) -117 |
| Los Angeles Dodgers | (-1.5) +149 | -130 | (U: 9) -105 | |
| Wednesday, May. 21, 01:15 pm |
Cleveland Guardians at | (+1.5) -220 | +104 | (O: 7.5) -105 |
| Minnesota Twins | (-1.5) +186 | -115 | (U: 7.5) -115 | |
| Wednesday, May. 21, 01:15 pm |
Houston Astros at | (-1.5) 118 | -141 | (O: 8.5) -117 |
| Tampa Bay Rays | (+1.5) -138 | +128 | (U: 8.5) -103 | |
| Wednesday, May. 21, 02:15 pm |
Seattle Mariners at | (-1.5) 110 | -151 | (O: 8) -120 |
| Chicago White Sox | (+1.5) -130 | +136 | (U: 8) +100 | |
| Wednesday, May. 21, 07:10 pm |
Texas Rangers at | (+1.5) -225 | +104 | (O: 7.5) -102 |
| New York Yankees | (-1.5) +189 | -115 | (U: 7.5) -118 | |
| Wednesday, May. 21, 10:10 pm |
Los Angeles Angels at | (+1.5) -142 | +139 | (O: 10.5) -120 |
| Athletics | (-1.5) +123 | -154 | (U: 10.5) +100 | |
| Wednesday, May. 21, 01:15 pm |
Baltimore Orioles at | (+1.5) -190 | +115 | (O: 8.5) +103 |
| Milwaukee Brewers | (-1.5) +165 | -127 | (U: 8.5) -124 | |
| Wednesday, May. 21, 01:20 pm |
Detroit Tigers at | (+1.5) -200 | +102 | (O: 8.5) -115 |
| St. Louis Cardinals | (-1.5) +174 | -112 | (U: 8.5) -105 | |
| Wednesday, May. 21, 06:50 pm |
New York Mets at | (+1.5) -170 | +125 | (O: 8) -105 |
| Boston Red Sox | (-1.5) +149 | -138 | (U: 8) -115 | |
| Wednesday, May. 21, 07:12 pm |
San Diego Padres at | (+1.5) -160 | +130 | (O: 8.5) -120 |
| Toronto Blue Jays | (-1.5) +138 | -143 | (U: 8.5) +100 |
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